Toll like receptor (TLR)-stimulated dendritic cells (DCs) are able to overcome the inhibitory activity of regulatory T cells (Tregs) and induce the proliferation of effector T cells. TLR-activated DCs secrete a soluble factor and act directly on Tregs to convert them into interferon γ-secreting TH1-like cells that express the transcription factor T-bet.
Affiliation
Department of Surgery and Harrison Department of Surgical Research; University of Pennsylvania; Philadelphia, PA USA ; Rena Rowan Breast Center; University of Pennsylvania; Philadelphia, PA USA.